Publications

Selected Publications

Franks, T.M., McCloskey, A., Shokirev, M.N., Benner, C., Rathore, A. and Hetzer, M.W. (2017) Nup98 recruits the Wdr82-Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells. Genes Dev. 31:2222-2234.

Buchwalter, A. and Hetzer, M.W. (2017) Nucleolar expansion and elevated protein translation in premature aging. Nat Commun. 8:328

Ibarra, A., Benner, C., Tyagi, S., Cool, J. and Hetzer M.W. (2016) Nucleoporin-mediated regulation of cell identity genes. Genes Dev. 30:2253-2258

Franks, T.M., Benner, C., Narvaiza, I., Marchetto, M.C., Young, J.M., Malik, H.S., Gage, F.H. and Hetzer, M.W. (2016) Evolution of a transcriptional regulator from a transmembrane nucleoporin. Genes Dev. 30:1155-71

Ibarra, A., Benner, C., Tyagi, S., Cool, J. and Hetzer M.W. (2016) Nucleoporin-mediated regulation of cell identity genes. Genes Dev. 30:2253-2258

Hatch, E.M and Hetzer W.M. (2016) Nuclear envelope rupture is induced by actin-based nucleus confinement. J. Cell Biol. 215:27-36

Ori, H., Toyama, B., Harris, M., Bock, T., Iskar, M., Bork, P., Ingolia, N., Hetzer, M.W., and Beck, M. (2015) Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats. Cell Systems

Mertens, J., Paquola, A., Ku, M., Hatch, E.M., Bohnke, L., Ladjevardi, S., McGrath, S., Campbell, B., Lee, H., Herdy, J.R., Goncalves, J.T., Toda, T. Kim, Y., Winkler, J., Yao, J., Hetzer, M.W., Gage, F.H. (2015) Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. Cell Stem Cell

Hatch, E.M. and Hetzer, M.W. (2015) Linking Micronuclei to Chromosome Fragmentation. Cell161:1502-1504

Jacinto, F.V., Benner, C. and Hetzer, M.W. (2015) The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing. Genes Dev. 29:1224-1238

Hatch, E.M. and Hetzer, M.W. (2015) Chromothripsis. Curr. Biol. 25:R397-399

Gomez-Cavazos, J.S. and Hetzer, M.W. (2015) The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis. J. Cell Biol. 208:671-681

Ibarra, A. and Hetzer, M.W. (2015) Nuclear pore proteins and the control of genome functions. Genes Dev. 29:337-349.

Buchwalter, A.L., Liang, Y. and Hetzer, M.W. (2014) Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics. Mol. Biol. Cell 25:2472-84

Hatch, E. and Hetzer, M. (2014) Breaching the nuclear envelope in development and disease. J. Cell Biol. 205:133-41

Buchwalter, A. and Hetzer, M.W. (2014) Nuclear pores set the speed limit for mitosis. Cell 156:868-869

Toyama, B.H., Savas, J.N., Park, S.K., Harris, M.S., Ingolia, N.T., Yates, J.R. and Hetzer, M.W. (2013) Identification of long-lived proteins reveals exceptional stability of essential cellular structures. Cell 154:971-82

Hatch, E.M., Fischer, A.H., Deerink, T.J. and Hetzer, M.W. (2013) Catastrophic nuclear envelope collapse in cancer cell micronuclei. Cell 154:47-60

Liang, Y., Franks, T.M., Marchetto, M.C., Gage, F.H and Hetzer, M.W. (2013) Dynamic association of NUP98 with the human genome. Plos Genet 9:e1003308

Toyama, B.H. and Hetzer, M.W (2013) Protein homeostasis: live long won’t prosper. Nature Rev. Mol. Cell Biol. 14:55-61

Franks, T.M. and Hetzer, M.W (2013) The role of Nup98 in transcription regulation in healthy and diseased cells. Trends in Cell Biol. 23:112-117

Savas*, J.N., Toyama*, B.H., Xu, T., YatesIII, J.R. and Hetzer, M.W. (2012) Extremely Long-lived Nuclear Pore Proteins in the Rat Brain. Science 335:942. *Equal Contributionhttp://www.ncbi.nlm.nih.gov/pubmed/22300851

D’Angelo, M.A., Gomez-Cavalos, J.S., Mei, A., Lackner, D.H. and Hetzer, M.W. (2012) A change in nuclear pore complex composition regulates cell differentiation. Dev Cell 22:446-58. http://www.ncbi.nlm.nih.gov/pubmed/22264802

Talamas, J. and Hetzer, M. (2011) POM121 and Sun1 play a role in early steps of interphase NPC assembly. J Cell Biol 194:27-37. http://www.ncbi.nlm.nih.gov/pubmed/21727197

Doucet, C.M., Talamas, J.A. and Hetzer, M.W. (2010) Cell Cycle-Dependent Differences in Nuclear Pore Complex Assembly in Metazoa. Cell 141:1030-1041. http://www.ncbi.nlm.nih.gov/pubmed/20550937

Capelson, M., Liang, Y., Schulte, R., Mair, W., Wagner, U. and Hetzer, M.W. (2010) Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes. Cell 140:372-382. http://www.ncbi.nlm.nih.gov/pubmed/20144761

D’Angelo, M.A., Raices, M., Panowski, S.H. and Hetzer, M.W. (2009) Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. Cell 136:284-295. http://www.ncbi.nlm.nih.gov/pubmed/19167330

 

All Publications

Franks, T.M., McCloskey, A., Shokirev, M.N., Benner, C., Rathore, A. and Hetzer, M.W. (2017) Nup98 recruits the Wdr82-Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells. Genes Dev. 31:2222-2234.

Buchwalter, A. and Hetzer, M.W. (2017) Nucleolar expansion and elevated protein translation in premature aging. Nat Commun. 8:328

Toda, T., Hsu, J.Y., Linker, S.B., Schafer, S.T., Mertens, J., Jacinto, F.V., Hetzer, M.W. and Gage, F.H. (2017) Nup153 interacts with Sox2 to enable biomodal gene regulation and maintenance of neural progenitor cells. Cell Stem Cell. 21:618-634

Van de Ven, R.A., de Groot, J.S., Park, D., van Domselaar, R., de Jong, D., Szuhai, K., van der Wall, E., Rueda, O.M., Ali, H.R., Caldas, C., van Diest, P.J., Hetzer, M.W., Sahai, E. and Derksen, P.W. (2016) p120 -catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis. Nat Commun. 7:13874

Hatch, E.M. and Hetzer, M.W. (2016) Nuclear envelope rupture is induced by actin-based nucleus confinement. J. Cell Biol. 215:27-36

Ibarra, A., Benner, C., Tyagi, S., Cool, J. and Hetzer M.W. (2016) Nucleoporin-mediated regulation of cell identity genes. Genes Dev. 30:2253-2258

Franks, T.M., Benner, C., Narvaiza, I., Marchetto, M.C., Young, J.M., Malik, H.S., Gage, F.H. and Hetzer, M.W. (2016) Evolution of a transcriptional regulator from a transmembrane nucleoporin. Genes Dev. 30:1155-71

Mertens, J., Paquola, A., Ku, M., Hatch, E.M., Bohnke, L., Ladjevardi, S., McGrath, S., Campbell, B., Lee, H., Herdy, J.R., Goncalves, J.T., Toda, T. Kim, Y., Winkler, J., Yao, J., Hetzer, M.W., Gage, F.H. (2015) Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. Cell Stem Cell 17:705-18

Ori, H., Toyama, B., Harris, M., Bock, T., Iskar, M., Bork, P., Ingolia, N., Hetzer, M.W., and Beck, M. (2015) Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats. Cell Systems 1, 224–237

Hatch, E.M. and Hetzer, M.W. (2015) Linking Micronuclei to Chromosome Fragmentation. Cell 161:1502-1504

Jacinto, F.V., Benner, C. and Hetzer, M.W. (2015) The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing. Genes Dev. 29:1224-1238

Hatch, E.M. and Hetzer, M.W. (2015) Chromothripsis. Curr. Biol. 25:R397-399

Gomez-Cavazos, J.S. and Hetzer, M.W. (2015) The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis. J. Cell Biol. 208:671-681

Ibarra, A. and Hetzer, M.W. (2015) Nuclear pore proteins and the control of genome functions. Genes Dev. 29:337-349.

Buchwalter, A.L., Liang, Y. and Hetzer, M.W. (2014) Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics. Mol. Biol. Cell. 25:2472-84.  

Hatch, E.M. and Hetzer, M.W. (2014) Breaching the nuclear envelope in development and disease. J. Cell Biol. 205:133-141.

Buchwalter, A. and Hetzer, M.W. (2014) Nuclear pores set the speed limit for mitosis. Cell 156:868-869.

Toyama, B.H., Savas, J.N., Park, S.K., Harris, M.S., Ingolia, N.T., Yates, J.R. and Hetzer, M.W. (2013) Identification of long-lived proteins reveals exceptional stability of essential cellular structures. Cell 154:971-982.

Hatch, E.M., Fischer, A.H., Deernick, T.J. and Hetzer, M.W. (2013) Catastrophic nuclear envelope collapse in cancer cell micronuclei. Cell 154:47-60.

Regner, B.M., Vu?ini?, D., Domnisoru, C., Bartol, T.M., Hetzer, M.W., Tartakovsky, D.M., Sejnowski, T.J. (2013) Anolalous diffusion of single particles in cytoplasm. Biophys J. 104:1652-1660.

Liang, Y., Franks, T.M., Marchetto, M.C., Gage, F.H and Hetzer, M.W. (2013) Dynamic association of NUP98 with the human genome. Plos Genet 9(2):e1003308

Toyama, B.H. and Hetzer, M.W. (2013) Protein homeostasis: live long won’t prosper. Nature Rev. Mol. Cell Biol. 14:55-61.

Franks, T.M. and Hetzer, M.W. (2013) The role of Nup98 in transcription regulation in healthy and diseased cells. Trends in Cell Biol. 23:112-117.

Gomez-Cacazos, J.S. and Hetzer, M.W. (2012) Outfits for different occasions: tissue-specific roles of nuclear envelope proteins. Curr. Opin. Cell Biol. 24:775-783.

Hatch, E. and Hetzer, M.W. (2012) RNP export by nuclear envelope budding. Cell 149:733-735.

D’Angelo, M.A., Gomez-Cacazos, J.S., Mei, A., Lackner, D.H. and Hetzer, M.W. (2012) A change in nuclear pore composition regulates cell differentiation. Dev. Cell 22:446-458.

Vargas, J.D., Hatch, E.M., Anderson, D.J. and Hetzer, M.W. (2012) Transient nuclear envelope rupturing during interphase in human cancer cells. Nucleus (LANDES) 3:88-100.

Savas, J.N., Toyama, B.H., Xu, T., YatesIII, J.R. and Hetzer, M.W. (2012) Extremely Long-lived Nuclear Pore Proteins in the Rat Brain. Science 335:942.

Hetzer, M. and Cavalli, G. (2011) Editorial overview. Cur. Opin. Cell Biol. 23:255-257.

Talamas, J. and Hetzer, M.W. (2011) Pom121 and Sun1 are involved in early steps of interphase nuclear pore assembly. J Cell Biol 194: 27-37.

Capelson, M., Doucet, C. and Hetzer, M.W, (2011) The nuclear pore complex: guardians of the nuclear genome. Cold Spring Harb Symp Quant Biol 75: 585-597.

Liang, Y. and Hetzer, M.W. (2011) Functional interactions between nucleoporins and chromatin. Curr. Opin. Cell Biol. doi: 10.1061/j.ceb.2010.09.008

Doucet, C. and Hetzer, M.W. (2010) Nuclear pore biogenesis into an intact nuclear envelope. Chromosoma 119: 469-477.

Doucet, C., Talamas, J. and Hetzer, M.W. (2010) Cell Cycle Dependent Differences in Nuclear Pore Complex Assembly in Metazoa. Cell 141: 1030-1041.

Hetzer, M.W. (2010) The role of the nuclear pore complex in aging of post-mitotic cells. Aging (Albany NY) 2: 74-75.

Hetzer, M.W (2010) The nuclear envelope. Cold Spring Harb. Perspect. Biol. 2:a000539.

Capelson, M., Liang, Y., Schulate, R., Mair, W, Wagner, U. and Hetzer, M.W. (2010) Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes. Cell 140: 372-383.

Hetzer, M.W and Wente. S.R. (2009) Border control at the nucleus: biogenesis and organization of the nuclear membrane and pore complexes. Dev. Cell 17, 606-616.

Anderson, D.J., Vargas, J., Hisao, J. and Hetzer, M.W. (2009) Recruitment of functionally distinct membrane proteins to chromatin mediates nuclear envelope formation in vivo. J. Cell Biol. 186: 183-191.

Capelson, M. and Hetzer, M.W. (2009) The role of nuclear pores in gene regulation, development and disease. EMBO Rep. 10, 697-705.

Dawson, R.T., Lazarus, M.D., Hetzer, M.W. and Wente. S.R. (2009) ER membrane-bending proteins are necessary for de novo nuclear pore complex assembly. J. Cell Biol. 184: 659-675.

D’Angelo, M.A., Raices, M., Panowski, S.H. and Hetzer, M.W. (2009) Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in post-mitotic cells. Cell 136: 284-295.

Kutay, U. and Hetzer, M.W. (2008) Reorganization of the nuclear envelope during open mitosis. Curr. Opin. Cell Biol. 20: 456-466.

Anderson, D.J. and Hetzer, M.W. (2008) Reshaping of the endoplasmic reticulum limits the rate for nuclear envelope formation. J. Cell Biol.182: 911-924.

D’Angelo, M.A. and Hetzer, M.W. (2008) Structure, dynamics and function of nuclear pore complexes. Trends in Cell Biol 18: 456-466.

Anderson, D.J. and Hetzer, M.W. (2008) The life cycle of the metazoan nuclear envelope. Curr Opin Cell Biol 20:1-7.

Anderson, D.J. and Hetzer, M.W. (2008) Reshaping the endoplasmic reticulum into the nuclear envelope. J Cell Sci 121:137-142.

Schulte, R., Talamas, J., Doucet, C. and Hetzer, M.W. (2008) Single bead affinity chromatography (SINBAD) for the detection of protein-protein interactions. Plos One 3:e2061.

Anderson, D.J. and Hetzer, M.W. (2007) Nuclear envelope formation by chromatin-mediated reorganization of the endoplamsic reticulum. Nat Cell Biol 9:1160-1166.

Franz, C, Walczak, R., Gentzel, M., Askjaer, P., Galy, V., Hetzer, M., Mattaj, I.W. and Antonin, W. (2007) Mel-28/ELYS is required for the recruitment of nucleoporins to chromatin and post-mitotic nuclear pore assembly. EMBO Rep 2:165-172.

D’Angelo, D.A. and Hetzer, M.W. (2006) The role of the nuclear envelope in cellular organization. Cell Mol Life Sci 63:316-332.

D’Angelo, D.A, Anderson, D.J., Richard, E. and Hetzer, M.W. (2006) Nuclear pores form de novo from the nucleoplasmic and cytoplasmic sides of the nuclear envelope. Science 312:440-443.

Hetzer, M.W., Walther, T.C. and Mattaj, I.W. (2005) Pushing the envelope: structure, function and dynamics of the nuclear envelope. Annu Rev Cell Dev Biol 21:347-380.

Hetzer, M. (2004) Nuclear assembly. Cell Biology Techniques. London, John Wiley and Sons Ltd.

Walther, T.C., Alves, A., Pickersgill, H., Loiodice, I., Hetzer, M., Galy, V., Hulsmann, B.B., Kocher, T., Wilm, M., Allen, T., Mattaj, I.W. and Doye, V. (2003) The conserved Nup107-160 complex is critical for nuclear pore complex assembly. Cell 113:195-206.

Walther, T.C., Askjaer, P., Gentzel, M., Habermann, A., Griffiths, G., Wilm, M., Mattaj I.W. and Hetzer, M. (2003) RanGTP mediates nuclear pore complex assembly. Nature 424:689-694.

Bilbao-Cortés, D., Hetzer, M., Längst, G., Becker, P.B. and Mattaj, I.W. (2002) Ran binds to chromatin by two distinct mechanisms. Curr Biol 9:1151-1156.

Hetzer, M., Gruss, O.J. and Mattaj, I.W. (2002) The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly. Nat Cell Biol 4:E177-184.

Hetzer, M., Meyer, H.H., Walther, T.C., Bilbao-Cortes, D., Warren, G. and Mattaj, I.W. (2001) Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly. Nat Cell Biol 3:1086-1093.

Hetzer, M. and Mattaj, I.W. (2000) An ATP-dependent, Ran-independent mechanism for nuclear import of the U1A and U2B” spliceosomal proteins. J Cell Biol 148:293-303.

Hetzer, M., Bilbao-Cortes, D., Walther, T.C., Gruss, O.J. and Mattaj, I.W. (2000) GTP hydrolysis by Ran is required for nuclear envelope assembly. Mol Cell 5:1013-1024.

Hetzer, M., Hiller, R., Schweyen, R.J. and Mueller, M.W. (2000) Transposition and exon shuffling by group II intron RNA molecules in pieces. J Mol Biol 297:301-308.

Hetzer, M., Hiller, R., Schweyen, R.J. and Mueller, M.W. (1997) DNA polymerization catalysed by a group II intron RNA in vitro. Nucleic Acids Res. 25:1825-9.

Hetzer, M., Wurzer, G., Schweyen, R.J. and Mueller, M.W. (1997) Trans-activation of group II intron splicing by nuclear U5 snRNA. Nature 386:417-420.