Hetzer Lab

Publications

Selected Publications

 

Hatch, E.M. and Hetzer, M.W. (2015) Linking Micronuclei to Chromosome Fragmentation. Cell 161:1502-1504

Jacinto, F.V., Benner, C. and Hetzer, M.W. (2015) The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing. Genes Dev. 29:1224-1238

Hatch, E.M. and Hetzer, M.W. (2015) Chromothripsis. Curr. Biol. 25:R397-399

Gomez-Cavazos, J.S. and Hetzer, M.W. (2015) The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis. J. Cell Biol. 208:671-681

Ibarra, A. and Hetzer, M.W. (2015) Nuclear pore proteins and the control of genome functions. Genes Dev. 29:337-349.

Buchwalter, A.L., Liang, Y. and Hetzer, M.W. (2014) Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics. Mol. Biol. Cell 25:2472-84

Hatch, E. and Hetzer, M. (2014) Breaching the nuclear envelope in development and disease. J. Cell Biol. 205:133-41

Buchwalter, A. and Hetzer, M.W. (2014) Nuclear pores set the speed limit for mitosis. Cell 156:868-869

Toyama, B.H., Savas, J.N., Park, S.K., Harris, M.S., Ingolia, N.T., Yates, J.R. and Hetzer, M.W. (2013) Identification of long-lived proteins reveals exceptional stability of essential cellular structures. Cell 154:971-82

Hatch, E.M., Fischer, A.H., Deerink, T.J. and Hetzer, M.W. (2013) Catastrophic nuclear envelope collapse in cancer cell micronuclei. Cell 154:47-60

Liang, Y., Franks, T.M., Marchetto, M.C., Gage, F.H and Hetzer, M.W. (2013) Dynamic association of NUP98 with the human genome. Plos Genet 9:e1003308

Toyama, B.H. and Hetzer, M.W (2013) Protein homeostasis: live long won't prosper. Nature Rev. Mol. Cell Biol. 14:55-61

Franks, T.M. and Hetzer, M.W (2013) The role of Nup98 in transcription regulation in healthy and diseased cells. Trends in Cell Biol. 23:112-117

Savas*, J.N., Toyama*, B.H., Xu, T., YatesIII, J.R. and Hetzer, M.W. (2012) Extremely Long-lived Nuclear Pore Proteins in the Rat Brain. Science 335:942. *Equal Contribution http://www.ncbi.nlm.nih.gov/pubmed/22300851

D’Angelo, M.A., Gomez-Cavalos, J.S., Mei, A., Lackner, D.H. and Hetzer, M.W. (2012) A change in nuclear pore complex composition regulates cell differentiation. Dev Cell 22:446-58. http://www.ncbi.nlm.nih.gov/pubmed/22264802

Talamas, J. and Hetzer, M. (2011) POM121 and Sun1 play a role in early steps of interphase NPC assembly. J Cell Biol 194:27-37. http://www.ncbi.nlm.nih.gov/pubmed/21727197

Doucet, C.M., Talamas, J.A. and Hetzer, M.W. (2010) Cell Cycle-Dependent Differences in Nuclear Pore Complex Assembly in Metazoa. Cell 141:1030-1041. http://www.ncbi.nlm.nih.gov/pubmed/20550937

Capelson, M., Liang, Y., Schulte, R., Mair, W., Wagner, U. and Hetzer, M.W. (2010) Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes. Cell 140:372-382. http://www.ncbi.nlm.nih.gov/pubmed/20144761

D’Angelo, M.A., Raices, M., Panowski, S.H. and Hetzer, M.W. (2009) Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. Cell 136:284-295. http://www.ncbi.nlm.nih.gov/pubmed/19167330

 

All Publications

Hetzer, M., Hiller, R., Schweyen, R.J. and Mueller, M.W. (2000) Transposition and exon shuffling by group II intron RNA molecules in pieces. J Mol Biol 297:301-308.

Hetzer, M. and Mattaj, I.W. (2000) An ATP-dependent, Ran-independent mechanism for nuclear import of the U1A and U2B" spliceosomal proteins. J Cell Biol 148:293-303.

Hetzer, M., Bilbao-Cortes, D., Walther, T.C., Gruss, O.J. and Mattaj, I.W. (2000) GTP hydrolysis by Ran is required for nuclear envelope assembly. Mol Cell 5:1013-1024.

Hetzer, M., Meyer, H.H., Walther, T.C., Bilbao-Cortes, D., Warren, G. and Mattaj, I.W. (2001) Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly. Nat Cell Biol 3:1086-1093.

Bilbao-Cortés, D., Hetzer, M., Längst, G., Becker, P.B. and Mattaj, I.W. (2002) Ran binds to chromatin by two distinct mechanisms. Curr Biol 9:1151-1156.

Hetzer, M., Gruss, O.J. and Mattaj, I.W. (2002) The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly. Nat Cell Biol 4:E177-184.

Walther, T.C., Alves, A., Pickersgill, H., Loiodice, I., Hetzer, M., Galy, V., Hulsmann, B.B., Kocher, T., Wilm, M., Allen, T., Mattaj, I.W. and Doye, V. (2003) The conserved Nup107-160 complex is critical for nuclear pore complex assembly. Cell 113:195-206.

Walther, T.C., Askjaer, P., Gentzel, M., Habermann, A., Griffiths, G., Wilm, M., Mattaj I.W. and Hetzer, M. (2003) RanGTP mediates nuclear pore complex assembly. Nature 424:689-694.

Hetzer, M. (2004) Nuclear assembly. Cell Biology Techniques. London, John Wiley and Sons Ltd.

Hetzer, M.W., Walther, T.C. and Mattaj, I.W. (2005) Pushing the envelope: structure, function and dynamics of the nuclear envelope. Annu Rev Cell Dev Biol 21:347-380.

D’Angelo, M.A. and Hetzer, M.W. (2006) The role of the nuclear envelope in cellular organization. Cell Mol Life Sci 63:316-332.

D’Angelo, M.A., Anderson, D.J., Richard, E. and Hetzer, M.W. (2006) Nuclear pores form de novo from both sides of the nuclear envelope. Science 312:440-443.

Anderson, D.J. and Hetzer, M.W. (2007) Nuclear envelope formation by chromatin-mediated reorganization of the endoplamsic reticulum. Nat Cell Biol 9:1160-1166.

Franz, C, Walczak, R., Gentzel, M., Askjaer, P., Galy, V., Hetzer, M., Mattaj, I.W. and Antonin, W. (2007) Mel-28/ELYS is required for the recruitment of nucleoporins to chromatin and post-mitotic nuclear pore assembly. EMBO Rep 2:165-172.

Anderson, D.J. and Hetzer, M.W. (2008) Shaping the endoplasmic reticulum into the nuclear envelope. J Cell Sci 121:137-142.  Accepted for publication prior to April 7, 2008

Anderson, D.J. and Hetzer M.W. (2008) Reshaping of the endoplasmic reticulum limits the rate for nuclear envelope formation. J Cell Biol 182:911-924. 

Anderson, D.J. and Hetzer, M.W. (2008) The life cycle of the metazoan nuclear envelope. Curr Opin Cell Biol 20:386-392.

D'Angelo, M.A. and Hetzer, M.W. (2008) Structure, dynamics and function of nuclear pore complexes. Trends Cell Biol 18:456-466.

Kutay, U. and Hetzer, M.W. (2008) Reorganization of the nuclear envelope during open mitosis. Curr Opin Cell Biol 20:669-677.

Schulte, R., Talamas, J., Doucet, C. and Hetzer, M.W. (2008) Single bead affinity detection (SINBAD) for the analysis of protein-protein interactions. PLoS ONE 3:e2061.

D’Angelo, M.A., Raices, M., Panowski, S.H. and Hetzer, M.W. (2009) Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. Cell 136:284-295. 

Dawson, R.T., Lazarus, M.D., Hetzer, M.W. and Wente, S.R. (2009) ER membrane–bending proteins are necessary for de novo nuclear pore formation. J Cell Biol 184:659-675.

Capelson, M. and Hetzer, M.W.  (2009) The Role of Nuclear Pores in Gene Regulation, Development and Disease. EMBO Rep 10:697-705.

Anderson, D.J., Vargas, J.D., Hsiao, J.P. and  Hetzer, M.W. (2009) Recruitment of functionally distinct membrane proteins to chromatin mediates nuclear envelope formation in vivo. J Cell Biol 186:183-191.

Hetzer, M.W. and Wente, S.R. (2009) Border control at the nucleus: biogenesis and organization of the nuclear membrane and pore complexes. Dev Cell 17:606-616.

Capelson, M., Liang, Y., Schulte, R., Mair, W., Wagner, U. and Hetzer, M.W. (2010) Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes. Cell 140:372-382.

Doucet, C.M., Talamas, J.A. and Hetzer, M.W. (2010) Cell Cycle-Dependent Differences in Nuclear Pore Complex Assembly in Metazoa. Cell 141:1030-1041.

Hetzer, M. and Cavalli, G. (2011) Editorial overview. Cur Opin Cell Biol 23:255-257.

Liang, Y. and Hetzer, M.W. (2011) Functional interactions between nucleoporins and chromatin. Curr Opin Cell Biol 23:65-70.

Talamas, J. and Hetzer, M. (2011) POM121 and Sun1 play a role in early steps of interphase NPC assembly. J Cell Biol 194:27-37.

D’Angelo, M.A., Gomez-Cavalos, J.S., Mei, A., Lackner, D.H. and Hetzer, M.W. (2012) A change in nuclear pore complex composition regulates cell differentiation. Dev Cell 22:446-58.

Vargas, J.D., Hatch, E.M., Anderson, D.J. and Hetzer, M.W. (2012) Transient nuclear envelope rupturing during interphase in human cancer cells. Nucleus 3:Jan 1st [ePub ahead of print]

Savas*, J.N., Toyama*, B.H., Xu, T., YatesIII, J.R. and Hetzer, M.W. (2012) Extremely Long-lived Nuclear Pore Proteins in the Rat Brain. Science 335:942. *Equ

 

 

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